Syphilis effects 13,000 people in the United States each year. It is widely known for its historical significance and devastating effects, with include:
- An ulcer or chancre, which occurs at the site of infection (primary syphilis)
- A rash in cohesion with flu-like symptoms, including fatigue, hair loss, and swelling of lymph nodes (secondary syphilis)
- Infection of the bones, blood, eyes, skin, nervous system, and heart (tertiary syphilis). Tertiary syphilis can lead to mental illness, blindness, and death
- 40% of untreated cases of syphilis progress to the tertiary stage
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